Defend — Saw Palmetto + Essential Nutrients for DHT Support
Support healthy DHT activity and help reduce shedding with our daily two-capsule formula.
How to use
- Take: two (2) capsules daily, with food.
- Time it: same time every day — most men take it with breakfast.
- Stay on it: DHT support is cumulative, so the protocol is the product.
Do not take within one hour of any daily medication. 60 capsules per bottle — a one-month supply.
Ingredients
Saw Palmetto Berry Extract — 300 mg — a botanical studied for its role in the 5-alpha-reductase pathway and in supporting healthy DHT activity.
Beta-Sitosterol / Plant Sterol Complex — 100 mg — 38–45% beta-sitosterol; plant compounds studied for supporting healthy hormonal balance.
Catalase Complex — 50 mg — an antioxidant enzyme that helps neutralize hydrogen peroxide buildup in the follicle.
Stinging Nettle Root Extract — 100 mg — a traditional botanical used alongside saw palmetto for DHT support.
Third-party tested. View the latest Certificate of Analysis →
What to expect
Month 1 · Block — Saw Palmetto and Beta-Sitosterol begin inhibiting 5-AR at the scalp, and shedding starts to slow.
Month 2 · Stabilize — daily shedding noticeably drops as DHT activity stays modulated. Hair texture and feel improves; existing strands anchor more securely.
Month 3+ · Sustain — DHT activity at the follicle stays consistently low. Existing hair holds and thickens.
Studied. Sourced. Stacked.
Four actives, every one of them disclosed at its dose and referenced in peer-reviewed literature. Every active is disclosed at its dose.
Saw Palmetto Extract
A berry extract from the Serenoa repens palm, studied for its role in the 5-alpha-reductase pathway — the enzyme step that converts testosterone into DHT. The lead active, and the backbone of the formula.
Beta-Sitosterol
A plant sterol complex standardised to 38–45% beta-sitosterol. Studied alongside saw palmetto for its role in supporting healthy hormonal balance and healthy DHT activity at the follicle.
Catalase Complex
An antioxidant enzyme that helps neutralise hydrogen peroxide buildup in the follicle — a source of oxidative stress linked in research to follicle stress and premature greying.
Stinging Nettle Root
A traditional botanical studied for its role in supporting healthy DHT levels through testosterone–SHBG binding. Included because it works synergistically with saw palmetto, not as filler.
What is it?
Defend is a daily oral protocol — two capsules, once a day — built around clinically dosed Saw Palmetto and Beta-Sitosterol, botanicals studied for their role in supporting healthy DHT activity at the scalp. No topical routine. No hormonal trade-off to sign up for.
Natural DHT defense
Saw Palmetto and Beta-Sitosterol are studied as 5-alpha-reductase inhibitors — the enzyme pathway at the center of hair-loss science, approached botanically.
Botanical 5-AR pathwaySupport, not just suppression
Catalase and stinging nettle root sit alongside the DHT actives — antioxidant and hormonal-balance support so the scalp keeps the conditions hair needs to hold.
Four actives · one capsuleThird-party tested · Made in USA
Every batch verified for potency and purity before it ships. Formulated and bottled in FDA-registered facilities in the United States.
Verified batch by batchHow does it work?
DHT is the androgen behind male pattern hair loss — it binds to receptors in susceptible follicles and miniaturises them, cycle by cycle, until the hair they produce is too fine to see. Defend works on the enzyme that makes it.
Modulate DHT at the source
Saw Palmetto and Beta-Sitosterol are studied for their role in inhibiting 5-alpha-reductase (5-AR), the enzyme that converts testosterone into DHT at the scalp. Less 5-AR activity means less DHT pressure on the follicle.
Beta-Sitosterol
Prime the scalp environment
Stinging nettle root and catalase support the environment around the follicle. Catalase is an antioxidant enzyme that helps neutralise hydrogen peroxide buildup — one of the oxidative stressors research associates with follicle stress.
Catalase Complex
Sustain the result
Defend works cumulatively. Every day you take it, DHT activity at the follicle stays modulated and the scalp keeps the conditions hair needs to hold. No on-off cycles, no rebound.
Botanical
A Modern
Epidemic.
Our forefathers had double the amount of hair we do. Stress, poor sleep, processed diets, and toxins are destroying our endocrine systems and our overall health.
The impact? Low sex drive, hair loss, and mental health issues — making it harder to perform at your best in life.
The good news: hair loss has never been more treatable. Maneup engineers clinically studied compounds — Copper Tripeptide-1, saw palmetto, the ABCN complex — into daily protocols built to help you reclaim your edge.
Built differently.
Clinically studied peptides, engineered into daily protocols — formulated, tested, and delivered under one roof. This is where hair care was always headed. We just got here first.
What to expect.
Defend is protective before it is cosmetic. Here’s the honest arc our users report — the first wins are the hairs you stop losing.
The pathway switches on
Saw Palmetto and Beta-Sitosterol begin inhibiting 5-AR at the scalp. Nothing visible yet — this is the enzyme work everything after it depends on.
Shedding starts to slow
DHT activity at the follicle comes down and shedding begins to slow. Most men notice it in the shower drain and on the pillow long before they notice it in the mirror.
Daily shedding noticeably drops
Daily shedding noticeably drops as DHT activity stays modulated. Hair texture and feel improves; existing strands anchor more securely.
Existing hair holds and thickens
DHT activity at the follicle stays consistently low. Existing hair holds and thickens, and the scalp environment settles into a steady state.
The defense compounds
Six months of consistent modulation. The hair you were losing is the hair you still have — the protective effect builds rather than plateaus.
A routine that lasts
A full growth cycle under a modulated DHT load. Defend is protective by design: you keep the result for as long as you keep the protocol.
Your results, guaranteed.
Backed by real research.
DHT — dihydrotestosterone — is the androgen behind male pattern hair loss. The botanicals in Defend have been studied for decades for their role in the 5-alpha-reductase pathway that produces it.
Decades in the literature
Saw palmetto has been studied in peer-reviewed research for decades, much of it centred on 5-alpha-reductase — the enzyme step that converts testosterone into DHT.
5-AR Pathway
Where DHT does the damage
Research describes DHT binding to receptors in genetically susceptible follicles and driving miniaturisation — follicles shrink cycle by cycle until the hair they produce is too fine to see.
Miniaturisation
Botanical, by design
The botanicals in Defend are studied for a local, measured effect on the 5-AR pathway — supporting healthy DHT activity at the scalp without touching hormones system-wide.
DHT Pathway
The Maneup Labs difference.
Other Brands13,000+ men. In their words.
“The DHT regulator is working wonders for my hair. It controls hair loss and boosts my Copper Peptide treatment results.”
“I’ve noticed long-term hair loss reduction since adding this DHT regulator. It works excellently with my Copper Peptide regimen.”
“This supplement helped control my scalp DHT, and my Copper Peptide formula is now even more effective. I love the results.”
“I’ve been using this DHT supplement for a while and it’s working great. It really improves the results from my Copper Peptide treatment.”
“My hair loss has slowed significantly thanks to this DHT regulator. It’s the perfect complement to my other hair products.”
“A solid supplement that controls DHT and enhances the effects of my Copper Peptide hair growth formula.”
“Since adding this DHT regulator supplement, my hair loss has decreased and my Copper Peptide formula shows better results.”
“I’m very happy with the DHT regulator. It controls scalp DHT effectively and makes my hair regrowth treatment more efficient.”
“This product is a game changer. The DHT regulator has stopped my hair loss and improved my Copper Peptide regimen.”
“I’ve been using this DHT supplement for extra support. It works perfectly with my Copper Peptide treatment for better hair density.”
“The DHT regulator supplement is amazing. It stops hair loss long term and boosts my Copper Peptide results.”
“I appreciate how this supplement helps control scalp DHT. My Copper Peptide formula now gives me better regrowth results.”
“Using the DHT regulator has really improved my hair growth. It works seamlessly with my other products.”
“I saw results quickly with this supplement. It controls DHT and makes my hair treatment with Copper Peptides more potent.”
“My hair has never looked better. The DHT supplement keeps my scalp balanced and works wonders with my Copper Peptide treatment.”